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Lyme Disease And Lyme Vaccine Disease

May/June 2010 Issue of Dogs Naturally Magazine
By: Dr. Patricia Jordan DVM

Over the last few years, 16,000 to 27,000 new cases of Lyme disease have been reported per year. The CDC listed 200,000 cases since the disease became reportable in 1991. Due to the high degree of difficulty in positive diagnosis of Lyme disease with true infection of Borrelia species, these numbers are difficult to confirm. There is much controversy over Lyme diagnosis as the tests are woefully inadequate in being able to help determine a definitive diagnosis.

Early diagnosis is essential to address true spirochete infection. To visualize the number and location for human cases you can visit www.cdc.gov/ncidod/dvd.d/lyme for maps and statistics.

In regard to dogs, the number of cases is unclear because of the lack of a central reporting agency. The closest thing we have to central reporting of Lyme disease in dogs is the DogsandTicks.com website where a map is kept of positive cases of Lyme Disease from the SNAP-4DX ELIZA test that is run in veterinary clinics across the US. 95% of the cases are found in just 12 states for the US. According to cumulative statistics recently released by IDEXX Laboratories Inc. however, nearly half the states (23) in the U.S. have re- ported more than 500 Lyme-positive dogs between 2001 and July 2009. An additional seven states logged between 251 and 500 cases and not a single state was free of Lyme-positive dogs.

In field cases for natural exposure to the Lyme Disease organism, following a incubation period of two to five months post tick bite, most dogs suffer no symptoms and simply test positive whereas 5% of exposed dogs get fever, anorexia and lameness. Most respond very quickly to Doxycycline, the antibiotic of choice.

In experiments done at Pennsylvania’s Veterinary School, of the Beagle puppies purposely infected with Borrelia burgdorferi (the spirochete attributed to Lyme disease), those who displayed symptoms experienced four days of self limiting lameness and fever and signs went away with- out any treatment.

As found in the field situation, experimental adult Beagle dogs exhibited no sickness at all: they just became Lyme positive on the test. None of the experimental infections performed at Penn’s Veterinary school found any of the dogs or puppies to suffer flu-like, cardiac or neurological symptoms.

Exposure to Lyme disease in dogs might be common in the field but disease pathology from the natural exposure certainly is not. 95% of exposed dogs simply do not get sick. Dr. Littman found this to be true experimentally. In the northeast portion of the country where Lyme disease positives are highest, 70-90% of healthy dogs have Lyme positive tests. Asymptomatic cases are not treated. They should however have urine protein tests to determine kidney involvement. Dogs that also test positive for Anaplasmosis, another tick disease are more likely to be the ones with symptoms. (Littman MP VMD, Dipl ACVIM Penn School of Vet Med).

In other breeds more significant symptoms have been reported; lymphadenopathy and more often in Labradors and Golden Retrievers, serious kidney disease with protein losing nephropathy which may not respond to antibiotics. This kidney disease however is immune mediated and relates to the immune response to the infectious agent antigens: or the antigens used in the Lyme vaccines.

This damage is from the immune system antibody as complexes with the antigen from either the natural organism exposure repeated or to the antigen from vaccines administered. Reports of Lyme Nephritis without any organisms found on renal bi- opsies lends one to realize that significant immunopathology results from the antigen as it engages with the immune system and the disease results just as easily from the vaccine as it does from exposure to natural infection. If the disease pathology can be triggered from antigen alone, that means that vaccines are capable of inducing dis- ease and that vaccines will convey cumulative damage with each administration.1, 2, 3

Indeed the pathological effects of painful arthritis and neurological disease including cognitive dysfunction can be conferred upon mammals through the vaccine for Lyme disease alone. The lipoprotein antigen used in all Lyme vaccines, including the Lymerix vaccine for humans (which was recalled for severe adverse events that occurred with the use of the vaccine) is now understood to generate autoimmune disease in vaccinated populations. 4,5

There is plenty of evidence that Lyme Vaccine Disease is caused in part by autoimmunity. 6,7,8 Indeed, the Fort Dodge whole bacterin vaccine can cause Lyme disease [Lyme vaccine Disease] without infection from any actual Borrelia. 9,10 Even severe local reactions from the bacterin vaccines have been reported.

The Lyme vaccines contain thimerasol (mercury) a neurotoxin and a genetic mutator which is very inflammatory. As early as 1935, there were warnings against its safety “even in dogs serum” to the Eli Lilly Company by Pittman Moore Animal Pharmaceutical Company. These safety issues were raised in Congressional testimony several times and the correspondence from Pittman Moore to Eli Lilly are a part of Congressional Hearings testimony on the dangers of mercury (thimerasol).

The whole bacterin vaccines were on the market for years for dogs despite the significant pathology associated with them and despite their removal from human medicine. Adverse events from these types of vaccines continue to plague our animals.

The Osp A recombinant DNA technology of the latest Lyme vaccines is touted as safe and yet despite the recall of the products in human Lyme vaccines due to safety issues, dogs also continue to be Lyme Vaccine Diseased from the use of these products. More pathology has been linked to the anti- gens of Borrelia, antigens which are also found in the Lyme disease vaccine.

Neurological syndromes that follow vaccination or infections are often attributed to auto immune mechanisms. There are numerous reports of neuropathy or cognitive impairment within several days to two months following vaccination with the OspA antigen; chronic inflammation demyelination polyneuropathies, multifocal motor neuropathy, sensory axonal neuropathy and cognitive impairment (seen on MRI). All of these disease patterns are also linked in humans to “chronic Lyme disease” and can also be considered “chronic Lyme vaccine disease”. These patterns of disease suggest the role of immune mechanisms in the manifestation of chronic Lyme disease will be resistant to antibiotic treatment. 11

An article titled “Pets fall victim to mental health problems too” lists cognitive dysfunction as a progressive disease with “no known cause” and advises treatment with drugs such as Selegeline (Anipryl), Senilife and Novofit. Coincidentally, the same drug company that makes the vaccines also makes drugs to treat vaccine diseases: yet they state cognitive dysfunction has no known cause and is progressive. Hills Prescription has a diet for this brain problem; the diet is called Brain Diet and has antioxidants and Omega 3 fatty acids, everything you would want to supplement a brain damaged with oxidative damage. It is vaccines which cause oxidative damage and they are directly linked to the formation of cognitive dysfunction. Oxidative damage also contributes to the state of chronic inflammation leading to cancerous developments.

The aluminum and mercury in vaccines allow vaccine components to travel directly up peripheral nerves and into the central nervous system. The aluminum increases the permeability of the blood brain barrier and allows the viruses, mercury, aluminum and antigens to enter directly into the central nervous system. Vaccines appear to be a serious biosecurity breech for the immune system and the disease that results from this Trojan horse is capable of the worst forms of pathology.

Can animals be suffering mental health problems from infections and from injections as are the humans? Travis a 15 year old domesticated chimp in Connecticut with Lyme Disease, (which is known to cause increased irritability), was acting agitated when his owner medicated the chimp with Xanax (an anti anxiety medication), in a bit of tea. Xanax has been shown to lead to aggression in people who are unstable to begin with. The Lyme disease infected chimp medicated with Xanax, tore the face off a 55 year old woman friend of the chimp’s caretaker. The chimp had not experienced any agitation prior to the Lyme disease.

A report which came to our service asked about changes in behavior following the Lyme vaccine. The report relayed that a dog had strange behavioral issues following the Lyme vaccine administration where he started circling the owner’s feet, trying to ‘herd’ her movements. The dog was not a herding breed. Following the administration of the second Lyme vaccine in three weeks, this time there was an increase in intensity.

First the dog increased his breathing, starting to pant and had respiratory difficulty. Once again he started the strange pacing movements circling the owner’s legs and feet, preventing her from moving. This time the dog was exhibiting more agitation and when the owner drew closer trying to examine him, the dog attacked her face, breaking the skin and drawing blood.

The neurological manifestations with Lyme disease or with Lyme vaccine disease include a wide range of symptoms including mood disturbance, confusion, depression, anxiety and adjustment syndrome as the spirochete is known to penetrate the pituitary gland. Many experts believe that Lyme disease can “rewire” the brain and affect personality. The CDC admits that 5% of patients may develop chronic neurological complaints months to years after infection (or injection), including obsessive compulsive disorders, Lyme Rage, behavioral changes and even stage fright (performance anxiety). All working dogs, agility dogs and performance dogs should especially be kept free from tick exposure and from pathology from the Lyme vaccine disease for this reason.

The information about the Osp A lipoprotein antigen of Borrelia and the pathway to disease was known as early as 1988. Scientific studies demonstrated that Osp A crossreacts with nerve cell axons, joint, synovial, heart and skeletal muscle protein and that the interaction results in autoimmune disease. The Osp A is found to be responsible for delayed hypersensitivity immune response and is a potent inducer of interleukin l, a cytokine with proinflammatory effects leading to cartilage and bone destruction.

The Osp A vaccine was approved for use in humans in 1998 despite the knowledge of this pathology, thanks to loop holes for reporting adverse events from the vaccine. The mechanism for Lyme Neuroborreliosis injury includes vasculitis, cytotoxicity neurotoxic mediators or autoimmune reaction via molecular mimicry. 12

Similar mechanisms of molecular mimicry and antigen specific T–cell responses have been recognized in both multiple sclerosis and chronic Lyme Neuroborreliosis. Some cases could not demonstrate spirochete but non specific perivascular or vasculature lymphocytic inflammations. This leads to the belief that T cells exacerbate the manifestations of Lyme Disease and have been found responsible for the observed immune mediated pathology. <sup>13</sup>  OspA vaccine-induced autoimmunity due to homology (almost an identical match) with mammalian cells was proven both in human and animal testing. Early reports showed several references to lab animals with autoimmune disease. The FDA was aware that there was a link between the vaccine and degenerative autoimmune disease. Favorite media mogul Martin Zuckerman helped push for the fast pass of the human Lyme vaccine and the FDA licensed the vaccine before safety studies were completed on the human Osp A vaccine. The drug company Smith Kline Beecham promised to do the safety studies but never did and the vaccine was delivered into the arms of many people.

During the extended reports from remarks given by Karen Vanderhoof-Forschner to the FDA Vaccine Advisory Committee Meeting in November, 2001, this information was admitted as testimony. The FDA’s written conclusion was to recall the human Lyme vaccine. They stated that the FDA should never again allow a pharmaceutical company to promise studies tomorrow for drug approvals today and that federal em- ployees should never be allowed to consult in areas where they set federal policy. Unfortunately, the FDA has not set its compass for true north and is still not operating under these obvious require- ments for ethical standards and is still not looking out for public safety over corporate profits.

VAERS (Vaccine Adverse Events Records Systems) lists the adverse events associated with the human Lyme vaccine as arthalgia, myalgia, pain arthritis, arthrosis, rheumatoid arthritis, facial paralysis, hypersensitivity reactions, thrombocytopenia, anemia, kidney compromise, heart disease and even some deaths: and one suicide. The CDC reported that all of the above adverse events were already found in clinical trials prior to vaccine licensing.

Lyme disease is also associated with endometriosis, abortions, miscarriages, still- births, perinatal deaths, kidney and liver disease, increased blood pressure, arrhythmias, decreased vision and decreased hearing. Furthermore, there is evidence of in-utero infection, (Dr. Alan MacDonald neonatal pathology specialist 1981), sexual transmission, transplacental passage and patterns of teratogenicity especially heart defects.

Immune mediated presentations include splenomegaly, uveitis and rheumatoid arthritis. Neurological disorders include increased irritability and aggression (all of which mercury in vaccines alone can induce) depression, confusion, overeating, nerve damage in limbs and face, Bells Palsy, hallucinations, sleep disorders, memory loss decreased concentration, seizures. Secondary disturbances of endocrine-adrenal dysfunction include gonadal deficiencies, hypothyroidism, insulin resistance, hypothalamus and pituitary function. This results in decreasing stimulating hormones for end organs including adrenal, growth hormone, testosterone, estro- gen, anti diuretic hormone.

Spirochetes have been found in breast milk, tears, semen urine, and babies via transplacental transfer and even via sexual intercourse. Why is the CDC ignoring this? The spirochetes can be transmitted in blood products and the antigen for inducing the pathology can be transmitted in vaccines. Dr. Lee Cowden warns: “only a very small percentage of those contracting Lyme disease though a tick bite, the way conventional medicine is fixated on recognizing”. Mosquitoes are now recognized for their ability to transmit Lyme disease.

Consider the fact that 95% of the naturally infected dogs at Penn State showed no symptoms despite testing as positive. Lyme disease in humans is likely more symptomatic because they have not been infected as long as dogs have. The term “ hard to catch and easy to cure” seems to be true for dogs and Lyme disease.

To add to insult, the Lyme vaccine manufacturer only considered side effect which occurred within 24 hours prior to releasing the canine vaccine. Research from Cornell University Veterinary School however lists long term effects from vaccination as rheumatoid arthritis to “all the symptoms of actual Lyme Disease to even death via acute renal failure”. Dogs would be affected 4-8 weeks post vaccination with the Lyme vaccine.

Dr. Ron Schultz, our leading veterinary vaccine researcher does not recommend the use of Lyme disease vaccines on his own dogs despite living in a Lyme endemic part of the country in Wisconsin. Dr. MP Littman Dip ACVIM of Penn School of Vet Med also does not recommend any Lyme vaccines. All of them recommend you keep the dogs free of ticks. Most of the tick control products we are recommending are also effective against mosquitoes and fleas two more vectors recently associated with spirochete transfer and vectors of blood borne diseases.

It would also be useful to list that none of the US Veterinary schools list the Lyme Vaccine on their recommended lists of vaccines for animals. The AVMA and AAHA also are not recommending Lyme vaccines as a part of core vaccination protocols. It is obvious to me that there are too many problems with all the Lyme vaccines on the market and with the outer surface antigens like OspA, there exists a larger problem with immunopathology, cross reactivity and molecular mimicry. Since the goal of vaccination is to prevent and thereby promote optimal patient and public health, none of which is achieved with the Lyme vaccine, it would be best to avoid the Lyme vaccination and associated propaganda.

I recommend that my patients take the precaution of being on Astragalus during tick seasons. Astragalus is but one herb that has immune-modulating abilities. There are many herbs that can be used to help the body against spirochete infections and even for treatment of Lyme disease nd Lyme Vaccine disease. *See Stephen Harrod Bruhner’s book Healing Lyme Natural Healing and Prevention of Lyme Borreliosis and its co-infections.

I see those suffering Lyme disease and Lyme vaccine disease also suffer many co-infections which points toward a dysregulated and dysfunctional immune system. All of the co-infections to date point to cell mediated immune suppression and this is what happens to many following vaccine administration with vaccine damage being cumulative. The vaccines, an abnormal pathogen delivered via an abnormal vehicle, remove healthy Th1 (cell mediated) immune system bias and replace the healthy immune system with a dysregulated immune system and Th2 (humoral) bias.

The cumulative damage from this process is atrophy of the mucosal immune system and paralysis of the cell mediated immune system. The cell mediated immune system is crucial for resolving everything that accompanies the co-infections which may be bacterial, viral, fungal, yeast, intestinal, parasitic or external in nature. In the long run, we must recognize the considerable harm that vaccines do against health. When demonstrable immunity from vaccines is unlikely and immunopathology is a very real risk, you must let go of the myth that vaccines somehow manufacture good health.

Most of the disease I see today in animals and in people is a reflection of this unnatural immune assault and the uncalculated damage to the immune system. Chronic and uncontrolled inflammation with loss of focus and control is exactly what leads to cancer, exhausted adrenals and early death.

Don’t fall victim to the advice of those who have not preformed due diligence in the needed investigation required before pushing the most dangerous medical practice act done with the most frequency in every veterinary hospital across the United States.

Lyme vaccines were removed from the human market because they failed to perform the proper safety studies prior to release and because of the numerous adverse events that followed the vaccine, some resulting even in death. Safety studies that evaluate the risk of carcinogenicity, teratogenicity, genetic damage, autoimmune disease, and immune mediated disease from vaccination are non-existent. Remember that when the vaccine in question has never established conveyance of immunity against said disease, or the pathology suffered in the disease, what exactly is the point of the prick?

Patricia Monahan Jordan is a graduate of the North Carolina College of Veterinary Medicine. She practiced conventional veterinary medicine for twenty years and founded six different veterinary facilities in North Carolina. Having worked for major veterinary employers in the United States, she has experienced an intimate look into the face of vaccine induced disease. Dr. Jordan has traced the paths of immunopathology to vaccine administration and uncovered the cycle of disease and the endless cycle of disease management that results from vaccine administration. Dr. Jordan can be reached at www.dr-jordan.com

References

  1. Reference; Marqus AR, Hornery RL, Dally L, Philipp WT, Detection of Immune Complexes is not independent of detection of antibody in Lyme Disease patients and does not contain active infection of Borrelia, Clinical and Diagnostic Laboratory Immunology Sept, 2005; 12 (9):1036-1040.
  2. Reference; Fowalt PT, Rose CD, Macubure V, Long term effects of immunization with recombinant lipoprotein outer surface protein on a serological test for Lyme dose Clin Diagn Immunol 11:808-80.
  3. Reference; NAVC Clinicians Brief Sept 2008 pg 46. [Western Blot C6 peptide antibody test serology and histopathology was positive but no intact Borrelia found.]
  4. Reference; Latov N, Wu AT, Chin RL, Sander HW Aledini A and Brannagan III TH, Neuropathy and cognitive impairment following vaccination with Osp A protein of Borrelia burgdorferi, Journal of the Peripheral Nerve Society,2004 Sept; 9(3);165-167.
  5. Reference; Otto A, Lyme Vaccine linked to autoimmune arthritis, Pharmacy Today, 2001; 7 (1):10.
  6. Reference; Hu LT, Klempme MS; Host pathogen interaction in the immunopathogenesis of Lyme Disease[Lyme Vaccine Disease]J Clin Immunol, 1997;17 (5):354-365.
  7. Reference; Sigal LH; Lyme disease [Lyme Vaccine Disease] A review of aspects of its immunology and immunopathogenesis, Am Rev Immunol,1997; 15:63-92. Sigal LH, Antibodies to spirochete antigens cross react within human nerve, synovial, hepatic, cardiac and skeletal tissue and linked to immune-mediated chronic inflamatory disease,1997;15:63-92.
  8. Reference; Wormser GP, Prospects for a vaccine to prevent Lyme Disease in humans, Clin Infect Dis, 1995; 21:1267-74.
  9. Reference; Appel MJG, Jacobson RH; CVT Update; Canine Lyme Disease in Bonagur JD (ed) Kirk’s Current Vet Therapy XII Phila, WB Saunders CO. 1995, pp 103-308 9.
  10. Reference; Appel MJG Lyme Disease vaccination in dogs in prevention and treatment, Proc Conn Vet Med Assoc., 1998: 1-10.
  11. Reference Latov N, Wu A, Chin RL et al.New Lyme Neuroborreliosis Emerging Zoonosis; Reference; Hildenbrand P, Craven DE, Jones R, et al, Review Article Lyme Neuroborreliosis manifestation of a rapidly Emerging Zoonosis, AJNR, 2009; 30:1079-87.
  12. Reference; Rupprecht TA, et al, The pathogenesis of LNB from infection to inflammation Mol Med 2008; 14:205-12.
  13. Reference; McKiser MD, Redmond WL, Barthud SW, Cutting Edge-T cells mediated pathology in Murine Lyme Borreliosis, Journal of Immunology, 2000; 164:6096-6099.
  14. Ref Nadelman RB, Nowakowski J, Fish D, et al., Prophylaxis with single dose Doxycycline for the prevention of Lyme disease after an Ixodes scapularis tick bite, NEJM 2001; 345 (2):79-84.
  15. NY epidemiologist Dr. Daniel Cameron

 

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